"CAGE SIDE OBSERVATIONS: Yes

- Time schedule: cages were checked for mortality in the morning and at the end of the normal working day.

- Cage side observations included observations of dead or moribund animals.

DETAILED CLINICAL OBSERVATIONS: Yes

BODY WEIGHT: Yes

- Time schedule for examinations: weekly, commencing 1 week prior to the start of exposures and when any possibly significant observations were made during daily checks or at anytime during the study.

FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study):

- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: No, this is not a feeding study, but food consumption is calculated as group mean values as grams/animal.

- Compound intake calculated as time-weighted averages from the consumption and body weight gain data: No

FOOD EFFICIENCY:

- Body weight gain in kg/food consumption in kg per unit time X 100 calculated as time-weighted averages from the consumption and body weight gain data: No data

WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): No data

HAEMATOLOGY: Yes

- Time schedule for collection of blood: week 4 of exposure

- Anaesthetic used for blood collection: No data

- How many animals: all animals

- Parameters checked in table [No. 1] were examined.

CLINICAL CHEMISTRY: Yes

- Parameters checked in table [No.2] were examined.

URINALYSIS: No

- Parameters checked in table [No.2] were examined.

NEUROBEHAVIOURAL EXAMINATION: Yes

- Time schedule for examinations: a full functional observation battery was performed during the pre-treatment period and during week 4. A shortened battery was performed during weeks 1, 2, and 3.

- Dose groups that were examined: All dose groups were tested.

- Battery of functions tested: Observations in the hand: ease of removing animal from cage, reactivity to handling, occurrence of convulsions, tremors, twitches, salivation/lacrimation, palpebral closure, exophthalmus, piloerection, fur appearance, vocalisation on handling; Observations in the arena: occurrence of convulsions, tremors, twitches, activity counts, level of arousal, rearing count, grooming, piloerection, assessment of gait/posture, record presence of fecal boluses, urine; Manipulations: approach response, touch response, auditory startle response, righting reflex, tail pinch response, pupil reflex, grip strength (fore and hindlimb), landing footsplay, body temperature and bodyweight.

Sacrice and pathology:

GROSS PATHOLOGY: Yes (see table 3)

HISTOPATHOLOGY: Yes (see table 4)"

Male Crl:CD BR Sprague-Dawley Rats