For exposure-response array data display purposes, the following results were coded (control and no effect findings were coded as "0", treatment-related increases were coded as "1", and treatment-related decreases were coded as "-1".

"6:2 FTOH-related changes in the incisor teeth, consistent with fluoride exposure, were present in males and females at 100 mg/kg/day. These changes included degeneration and atrophy of ameloblastic epithelium, accentuation of the normal laminar pattern of dentin and an increase in observed incomplete decalcification of enamel and/or dentin. Degeneration and atrophy of ameloblasts was characterized by segmental disorganization and attenuation of ameloblastic epithelium of the incisor teeth. Lamination of dentin was characterized by the presence of concentric basophilic rings within the dentin of these teeth. Incomplete decalcification of enamel and dentin was characterized by an increase in the observed presence of basophilic, mineralized debris in the enamel space of the incisor between the dentin and the gingiva. Normally, this material is lost during processing of slides and is not visible, but it is observed sporadically in control mice due to vagaries in processing. However, this finding was observed at a higher incidence and extent in males and females administered 100 mg/kg/day. Incomplete decalcification of nasal bones, also consistent with fluoride exposure, was observed in some animals at the 100 mg/kg/day dose level. There were no adverse changes in the teeth of males or females at dose levels ≤25 mg/kg/day."

P0 Female Crl:CD1(ICR) Mice