"HAEMATOLOGY: Yes

- Time schedule for collection of blood: at end of dosing period and at end of recovery period

- Anaesthetic used for blood collection: Yes (ether)

- Animals fasted: Yes

- How many animals: all animals of the respective groups

- Parameters examined were red blood cell count (RBC), white blood cell count (WBC),

hemoglobin concentration (Hb), hematocrit value (Ht), mean corposcular volume (MCV),

mean corposcular hemoglobin (MCH), mean corposcular hemoglobin concentration (MCHC),

platelet count, reticulocyte count, prothrombin time (PT), activated partial thromboplastin

time (APTT), differentiation of leukocytes (neutrophils, eosinophils, basophils, lymphocytes,

monocytes, large unstained cells (LUC)."

"Statistics: Data regarding body weights (excluding those at the time of necropsy) food intakes,

hematological examinations, blood chemical examinations, urine volume and specific

gravity, organ weights, grip strength and locomotor activity count were analyzed using the

Bartlett's test for homogeneity of variance. If the variances were homogeneous at a

significant differences in this analysis, the difference between the vehicle control group and

each of the treatment group was analyzed by the nonparametric Dunnett's test.

FOB numerical data was analyzed using the Kruskal-Wallis's test. If there was a significant

difference in this analysis, the difference between the vehicle control group and each of the

treatment groups was analyzed by the nonparametric Duenna's test."

Female Crl:CD(SD) Rats