For exposure-response array data display purposes, the following results were coded (control and no effect findings were coded as "0", treatment-related increases were coded as "1", and treatment-related decreases were coded as "-1".

"Laboratory Findings: No treatment-related changes in haematological parameters were noted. Clinical chemistry parameters revealed an increase, which was not concentration related, in glucose content in males and females of the upper mid and high concentration groups and in males of the lower mid concentration group. Significantly increased albumin levels were observed in males of the lower mid, upper mid and high concentration groups. The albumin/globulin ratio was significantly, but not concentration-related, increased in all male exposure groups. GGT was significantly increased in females of the high concentration group. Further, a significant increase in triglyceride levels was found in males of the lower and upper mid concentration groups and in females of the upper mid and high concentrations. Cholesterol levels were significantly, but not concentration-related, decreased in males of the low, lower mid and high concentration groups. A tendency towards a decreased cholesterol content was also seen in males of the upper mid concentration group. Phospholipid levels were increased in all female exposure groups reaching a statistically significant degree in females of the upper midconcentration group only. Finally, creatinine was significantly decreased in female animals of the high concentration group. At the end of the 14-day recovery period, glucose was increased in the / exposed animals and the increase was significant in males. Albumin was slightly though significantly increased in exposed male animals, a similar increase in female animals was not significant. The albumine/globulin ratio was significantly increased in exposed male animals and significantly decreased in exposed female animals. Cholesterol was significantly increased in exposed female animals. Phospholipids were increased in both male and female exposed animals. Creatinine was decreased in male exposed animals, a similar decrease in female exposed animals did not reach significance. An increased mean urinary fluoride concentration was observed in males and females of the upper mid and high concentration groups, and in males of the lower mid concentration group at the end of the treatment period. Accordingly, total fluoride excretion in urine and the urinary fluoride /creatinine ratio were also significantly increased in a concentration-related fashion in these male and female groups. These parameters were still slightly increased when compared to controls at the end of the recovery period. "

Male Wistar Crl:(WI)WU BR Rats