The concentrations in ppm are the nominal concentrations. The study summary also reports the analytical results in ppm and mg/L for each concentration level. The values in mg/m3 represent the analytical results.

"Route of administration: inhalation: vapour

Type of inhalation exposure: whole body

Vehicle: clean air

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION

Exposure apparatus: stainless steel exposure chamber, not further specified
Exposure chamber volume: 1.06 m³
Source and rate of air: indoor air
Method of conditioning air: filtered
System of generating particulates/aerosols: test material was evaporated by bubbling in a heated atmosphere
Treatment of exhaust air: charcoal filter
Temperature, humidity, pressure in air chamber: 22-25°C, 30-70%, 0-15 mm Aq

TEST ATMOSPHERE

Brief description of analytical method used: gas chromatography every 15 minutes
Samples taken from breathing zone: yes

Details on analytical verification of doses or concentrations: Test atmosphere concentrations were verified by gas chromatography. The analytical data indicated that the variance between nominal and actual concentrations were acceptable.

Duration of treatment / exposure: 28 days

Frequency of treatment: 6 h/day, 5 days/week, for 4 weeks

No. of animals per sex per dose: 5 males and females at each concentration in the main study, 5 males and females (control, 640 and 1600 ppm) in the 14-day recovery group

Control animals: yes, concurrent vehicle

Details on study design: - Post-exposure recovery period in satellite groups: 14-day recovery period for control, 640, and 1600 ppm male and female animals"

Male CD (SD) Rat