"3 groups of 25 bred females (25 per exposure group) and 25 bred control females exposed to filtered air

- Dose selection rationale: Doses were determined based on a previous 13 week inhalation study

- Rationale for animal assignment (if not random): Random"

"GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION

- Exposure apparatus: 1 cubic meter stainless-steel and glass exposure chambers. (Four chambers one for each exposure concentration and one for the control group exposures)

- Method of holding animals in test chamber: No data - Source and rate of air: 12 to 15 air changes per hour

- System of generating particulates/aerosols: Vapors were generated using a glass-bead column-type vaporization system

- Temperature, humidity, pressure in air chamber: 18 to 26 degrees C, 30 to 70% humidity, under slight negative pressure

- Air change rate: 12 to 15 air changes per hour

- Method of particle size determination: Casella Microdust 880 nm Aerosol Monitoring System was used for particle evaluation

- Treatment of exhaust air: No data TEST ATMOSPHERE - Brief description of analytical method used: Exposure concentrations were calculated for each test substance chamber from the total amount of the substance consumed during the exposure and the total volume of air passed through the chamber during exposure. Analyzed exposure concentrations were also determined at approximately 45-minute intervals using a gas chromatograph (GC) under the control of the WINH system

- Samples taken from breathing zone: yes

USE OF RESTRAINERS FOR PREVENTING INGESTION: No data"

Analytical Verification of doses/concentrations: "Analyzed exposure concentrations were determined at approximately 45-minute intervals using a gas chromatograph (GC) under the control of the WINH system"

Doses calculated from ppm values noted in results section based on a molecular weight of 316.05 g/mol identified online using the CASRN reported.

F1 Male and Female Sprague Dawley [Crl:CD(SD)] Rats