For exposure-response array data display purposes, the following results were coded (control and no effect findings were coded as "0", treatment-related increases were coded as "1", and treatment-related decreases were coded as "-1".

Clinical signs during exposure, lethal levels: "Face-pawing, lacrimation, salivation, irregular breathing, gasping, hyperemia, incoordination, unresponsiveness, unconsciousness and death. Onset, severity, and duration of all of these signs were dose related. Corneal opacity appeared in all succumbing rats immediately after death."

Clinical signs during exposure, non-lethal levels: "Same as lethal levels except no deaths. Onset, severity and duration of signs dose related."

Clinical signs immediately post-exposure, lethal levels: "Unconsciousness, loss of righting reflex, labored breathing, rales, hyperemia, pupillary dilation with accommodation. Duration and severity of these signs were dose related."

Clinical signs immediately post-exposure, non-lethal levels: "Same as lethal levels except no pupillary dilation."

Clinical signs 1-14 days post-exposure, lethal levels: "Inactivity and weight loss first day. Normal thereafter."

Clinical signs 1-14 days post-exposure, non-lethal levels: "Same as lethal levels"

"Except for the absence of nasal drainage in the rats in this present test, the clinical signs observed in the present test were essentially the same as those observed in the previous acute test at comparable levels (1). Thus, HFIP must still be considered a respiratory irritant."

Note: There was no un-exposed (control) group.

Male ChR-CD Rats