For exposure-response array data display purposes, the following results were coded (control and no effect findings were coded as "0", treatment-related increases were coded as "1", and treatment-related decreases were coded as "-1".

"During the TriF exposure, male and female rats from the high-exposure group exhibited severe convulsions immediately upon start of the exposure. The male rats had continuous convulsions while the females had periodic convulsions. Moderate dyspnea started approximately 20 minutes into the exposure. Red discoloration of the hair of face was observed for all five male rats and for two female rats from the high-exposure group. This discoloration was probably blood from bite wounds observed in the animals' tongues at gross necropsy. Also observed for the high-exposure group were wet facial hair from saliva (two female rats), and wet abdominal hair wet from urine (five of five female rats). Male and female rats from the mid-exposure group exhibited minor convulsions, severely reduced general activity, and partially closed eyes. The exact onset or frequency of the convulsions in the mid-exposure group was not noted. Male and female rats from the low-exposure group exhibited a moderate (male) to minor (female) reduction in general activity, and partially closed eyes. A single low-exposure male was observed to exhibit tremors; however, the time and/or frequency of these tremors was not recorded. Immediately following termination of the exposure, the surviving high-exposure female rat exhibited abdominal hair wet with urine, the mid-exposure male and female rats exhibited a minor to moderate reduction of general activity, and the low-exposure male and female rats exhibited a minimal reduction of general activity. All surviving animals appeared normal when examined 16 hours after exposure termination and throughout the subsequent 14-day observation period."

Male CD(SD)BR Rats