For exposure-response array data display purposes, the following results were coded (control and no effect findings were coded as "0", treatment-related increases were coded as "1", and treatment-related decreases were coded as "-1".

"Clinical chemistry values, detailed in part in the Tables 3-6, reflected an integrated picture of primary effects on the kidneys. These renal effects were more pronounced in the males. Total proteins were decreased in the males (significantly at 60 days in the 30 and 90 ppm groups by 3 and 7%, respectively, and at the end of recovery in the 10 and 90 groups by 2 and 7%, respectively) and females (in the 30 and 90 ppm recovery only by 9%) in a generally dose responsive manner. Albumin was significantly (p G 0.05) reduced in 90 ppm males (at 60 and 90 days and at the end of the recovery period by 7, 8, and lo%, respectively) and in the 10,30, and 90 ppm recovery group females. Blood urea nitrogen was increased (at 60 days in 10 ppm males only 11%) and decreased in 90 ppm females at 30 days and at the end of the recovery period ( 10 and 12%, respectively). Alkaline phosphatase was increased in males at 30 (3 ppm only) and 90 days (3, 10, and 90 ppm by 13, 12 and 14%, respectively) and only in the 90 ppm group (17%) at recovery, but at no point was there a dose-responsive trend. In females, alkaline phosphatase values were significantly (significant in the 30 ppm group, but to a decreased in the 90 ppm group at 30 and 60 nonsignificant extent in the other treatment days (2 1 and 12%, respectively), then were group, 9, 13, and 9%, respectively). significantly increased at 90 days (13%) and Serum electrolytes also showed changes in all groups at the end of the recovery period late in the study. Sodium was significantly increased in 10 ppm recovery group males (2%) and in 30 and 90 ppm recovery group females (2 and I%, respectively). Chloride was significantly decreased in 10 and 90 ppm males at 30 days (2 and 3%, respectively), in 3 ppm females at the end of recovery only (4%), and in 10,30, and 90 ppm females at 90 days and at the end of recovery ranging from 2 to 5% (in the females a clear dose-responsive pattern was present). Serum creatinine levels were significantly increased in 10, 30, and 90 ppm males at 30 days (15, 18, and 27%, respectively) and at the end of recovery (but not at other intervals), and in females at 30 (10 and 90 ppm), 60 ( 10 and 90 ppm), and 90 (3, 10 and 30 ppm) days. The 90 ppm recovery group females had significantly decreased serum urea levels ( 14%). Urinary creatinine was sign& cantly decreased in males at 30 (3,30, and 90 ppm groups by 24,26, and 30%, respectively) and 90 days, with a clear dose-responsive pattern of decreases in all male groups at 60 and 90 days. Female urinary creatinine levels were also significantly decreased in a dose-responsive but not statistically significant manner at 30 and 60 days. Finally, in what was probably an artifactual finding, the urine pH of the 30 ppm male recovery group animals was significantly increased. There were no significant effects on urine osmolarity."

Male Fischer F344 Rats