Create separate experiments for different chemicals and studies.

90-day studies

Mortality

Body weight, body weight gain, food consumption, acoustic startle response, ophthalmology - dummy variables except extract terminal body weight of HFC-236ea males reported in Table 3

Clinical chemistry, hematology, and urinalysis - dummy variables for each endpoint measured (except don't need to extract fluoride)

Table 3 (HFC-236ea) terminal body weight, testes weight, and incidence of testicular effects

All other organ weights and histopathology - dummy variables for each organ/tissue evaluated for both chemicals

Developmental studies (different experiments for different chemicals, but different species can be included under the same experiment, create different animal groups)

HFC-236fa Developmental studies

Mortality (if possible)

Acoustic startle response (rats only), clinical observations (rabbits only) - dummy variables

Tables 8 and 9 - extract maternal weight change and food consumption for the dosing periods only, extract all reproductive outcome data except for No. mated (and No. pregnant is the sample size not an endpoint), extract all means per litter

For Malformation results, create 2 endpoints "Fetal Malformations, Total" and "Fetal Variations, Total" and use dummy variables to indicate the incidence of developmental variations and malformations was not different from control incidence for either species. In results notes explain that the total incidence is not reported, but individual malformations and variations are reported in Table X (use correct table number for each group) and copy and paste qualitative statement from the study report.

HFC-236ea Developmental studies

Mortality (if possible)

Acoustic startle response - dummy variables

Table 12 - extract maternal weight change and food consumption for the dosing period only, extract all reproductive outcome data except for No. mated (and No. pregnant is the sample size not an endpoint), extract all means per litter

For Malformation results, create 2 endpoints "Fetal Malformations, Total" and "Fetal Variations, Total" and use dummy variables to indicate the incidence of developmental variations and malformations was not different from control incidence. In results notes explain that the total incidence is not reported, but individual malformations and variations are reported in Table 13 and copy and paste qualitative statement from the study report.

Table 13 - extract only fetal incidence of "Sternebrae, Retarded Ossification"

P0 Female Hra: (NZW) SPF Rabbits