For exposure-response array data display purposes, the following results were coded (control and no effect findings were coded as "0", treatment-related increases were coded as "1", and treatment-related decreases were coded as "-1".

"Narcosis was seen in the dogs during the exposures at I 0,000 ppm but not at I 000 ppm. This effect was reversible immediately upon cessation of the exposure. There was no effect on body weight. Organ weights were not evaluated. After 2 and 3 months of exposure, the dogs exposed to 10,000 ppm of HCFC 123 had lower erythrocyte counts, hemoglobin concentrations, and hematocrits compared to controls. This effect was not seen in the I 000 ppm exposure level group. Increases in SGOT, SGPT, and alkaline phosphatase were also seen at 10,000 ppm. An increase in alkaline phosphatase was also seen at I 000 ppm. Dogs exposed to 10,000 ppm of HCFC 123 exhibited degenerative changes in the liver as evidenced by both gross and microscopic changes. Grossly, the livers of the high level dogs all appeared pale brown with one of four showing focal red-brown areas and depressed foci scattered on the visceral surface. Microscopic changes were characterized by hypertrophy, clear cytoplasmic alteration, and necrosis of liver cells with inflammatory cell infiltration. There were no gross or microscopic changes seen at I 000 ppm. Overall, I 000 ppm was a no-observed-adverse effect level for the dogs."

Male Beagle Dog (D-78)