For exposure-response array data display purposes, the following results were coded (control and no effect findings were coded as "0", treatment-related increases were coded as "1", and treatment-related decreases were coded as "-1".

"The average exposure levels achieved during the study were 0, 4,037, 10,288, and 15,058 ppm. These were within 3% of the target. The nominal concentration was determined based on the total test material consumed for all three exposures (daily) and was 28,692 ppm, which was 97.6% of the sum of the measured average exposures. There was no mortality and no reports of abnormal test article– related clinical observations. There were no effects on body weights or food consumption or on gross observations of exposure-related abnormalities. Though there was a reduced pregnancy rate in the 4,000- and 10,000- ppm exposure-level groups (91, 73, 77, and 91% for control, 4,000-, 10,000-, and 15,000-ppm groups, respectively), as impregnation occurred before treatment, this was not treatment related. There was no difference between the groups regarding the number of corpora lutea, number of implantations, or sex ratio. There was both a decrease in preimplantation and an increase in postimplantation loss in the HFO-1234ze-exposed rabbits, compared to the controls. Preimplantation loss occurred before treatment and thus was not treatment related. Also, because these did not follow an exposure-related pattern, they may have been coincidental (Table 3). Postimplantation losses observed in the three treatment groups also were within laboratory historical control levels."

N values calculated based on pregnancy percentages. 22 animals were allotted to each treatment group. 91, 73, 77, and 91% for control, 4,000-, 10,000-, and 15,000-ppm groups, respectively. 22 Does per group was calculated to be 20, 16, 17, and 20 for control, 4,000-, 10,000-, and 15,000-ppm groups, respectively.

P0 Female New Zealand White Rabbit