4-week study - all results reported qualitatively only, use dummy variables for all endpoints (except mortality)

Mortality - incidence 0

Clinical observations, body weight, body weight gain, food consumption - no effects

Hematology, clinical chemistry - create endpoints for each parameter measured. Most were unchanged but indicate significant increases or decreases for some of the parameters as reported in the text. For parameters that were only significant after the recovery phase (and not at the end of exposure), extract the recovery timepoint (for example, male animals showed an increase in urea after recovery, but not after exposure so extract the endpoint as "Blood Urea, Recovery"). Note: we select NOAEL/LOAEL based on statistical significance but add comments to result notes that the authors did not consider these changes to be treatment-related.

Organ weights - create absolute and relative organ weight endpoints for each organ weighed - no effects except for absolute and relative liver weight in males after recovery (extract those as recovery endpoints, but the other organs at the end of exposure period).

Histopathology - create general histopathology endpoints for each tissue examined (e.g., "Heart Histopathology, Abnormal") and indicate no treatment-related effects. Note: tissues were only examined in the control and high-exposure groups. Leave N blank (not zero) for groups not examined.

90-day study - all results reported qualitatively only, use dummy variables for all endpoints (except mortality)

Mortality - incidence 0 except 1 female died in the 5000 ppm group

Clinical observations, ophthalmology, body weight, body weight gain, food consumption - no effects

Hematology, clinical chemistry - create endpoints for each parameter measured and indicate significant changes as reported in text. Note: we select NOAEL/LOAEL based on statistical significance but add comments to result notes that the authors did not consider these changes to be treatment-related.

Organ weights - create absolute and relative organ weight endpoints for each organ weighed - no effects

Histopathology - create general histopathology endpoints for each tissue examined (e.g., "Heart Histopathology, Abnormal") and indicate no treatment-related effects. Note: tissues were only examined for control and high-exposure groups (except for pancreas which was examined in all female groups). Leave N blank (not zero) for groups not examined. For female pancreas, copy and paste this into results notes: "To exclude a possible exposure-related lesion in the pancreas of female animals of the high-level exposure group, this organ was also examined in female animals of the low- and midlevel-exposure groups."

Developmental study - all results use dummy variables (except maternal mortality)

P0 endpoints

Mortality, clinical observations, maternal body weight, maternal food consumption, fecundity index, gestation index, corpora lutea, number of live fetuses, sex ratio

F1 endpoints combined sex

two or more wavy ribs, delayed ossification sternebra, delayed ossification inner parietal - significantly increased incidence in all exposed groups (LOAEL should be lowest exposure level) but copy and paste authors conclusions about these findings into the results notes.

external abnormalities, visceral abnormalities, skeletal malformations or variations, total - no effects

F1 endpoints separated by sex

fetal weight, absolute placenta weight (significantly increased in all exposed groups of both sexes)

F1 Wistar Rats