13-week Rat

Table 4: survival, final, change

Table 5

Table F2

Table G2 all results EXCEPT neutrophil, lymphocytes, monocytes, eosinophils, fluoride, volume (concentrated), specific gravity (concentrated)

Table H1 sperm parameters

Table H2 estrous cycle length and % of cycle in diestrus

13-Week Mice

Table 14: survival, final, change

Table 15

Table F5

Table G5 all results EXCEPT neutrophil, lymphocytes, monocytes, eosinophils, fluoride

Table H3 sperm parameters

Table H4 estrous cycle length and % of cycle in diestrus

2-year Rat

Tavle 6: animals surviving to study termination

Tables 7+8::week 103

Table 9:15 months-single sections

Table 9: 2-years-combined results for endpoints available single section for the others

Table 10 overall rates when multiple rates provided

Table 11 overall rates only

Table F3

Table G3 all results EXCEPT neutrophil, lymphocytes, monocytes, eosinophils, fluoride; for volume and specific gravity only extract the Week 64 data

2-year Mice

Tavle 16: animals surviving to study termination

Tables 17+18::week 94

Table1 9:15 months-all except hepatocellular adenoma, multiple

Table 19: 2-years-angictasis, eosinophilic focus, necrosis, Hemangioma or Hangiosarcoma, hepatocellular carcinoma, and hepatocellular adenoma or carcinoma

Table 20 overall rate, but note in the results noted the organs where they were observed.

Table 21

Table 22 2 year data only

Table F6

For histopathology for all studies: only extract incidence data unless otherwise instructed; for any organ mentioned in Table 1 but not specifically called out in a table of results, create a broad histopathology endpoint and use dummy variables based any information provided in the text. Lack of discussion can be considered no effect.

Female F344/N Rats