13-week study

Mortality - extract quantitatively based on description in text

Hyperactivity - dummy variables

Hematology - use description in text to extract treatment-related increases and decreases that were observed (either at 4 weeks or 13 weeks) using dummy variables. Also add endpoints that were listed in the methods but not mentioned in the results and assume no changes.

Clinical chemistry -

Table 4 - only extract glucose, calcium, ALT, globulin, and triglycerides

Table 5 - only extract Thyroglobulin, T3, T4, rT3, and TSH

Body and organ weights -

Table 6 - extract all endpoints

Create endpoints for organ weights listed in methods but not included in Table 6 and use dummy variables

Histopathology -

Nasal Turbinates, Rhinitis and Testis, Degeneration observed at 4 weeks - extract quantitatively (if possible) based on description in text. If you can't determine incidence in each group, use dummy variables for each group instead.

Table 8 (13 weeks) - extract incidence values for all lesions (convert percentage incidence into incidence using the number of rats examined for each tissue)

Create histopathology endpoints for all organs/tissues listed in methods for the 13-week evaluation but not included in Table 8 and use dummy variables (qualitative statement that all other changes were unrelated to exposure)

F344 Rats