"For exposure-response array data display purposes, the following results were coded (control and no effect findings were coded as "0", treatment-related increases were coded as "1", and treatment-related decreases were coded as "-1"

The authors report incidence of specific anomalies in a results table (numbers given below), but none were significant

Data are presented as number of litters (foetuses) affected:

Skeletal, Number examined: 22(100), 20(91), 19(98)

14th rudimentary rib 16(51), 16(53), 19(69)

Wavy ribs 8(17), 6(8), 5(7)

Sternebrae unossified 10(14), 9(16), 12(23)

Bipartite centra 3(3), 0, 2(2)

Hyoid unossified 2(3), 0, 4(6)

From Results:

Details on maternal toxic effects: Maternal toxic effects: no effects

Details on embryotoxic / teratogenic effects:

Embryotoxic / teratogenic effects: no effects

Details on embryotoxic / teratogenic effects: Petechial haemorrhages and small subcutaneous hematomas on various parts of the body and the number of runts among litters and foetuses were similar in all groups. Apparent hydronephrosis, transposition of the viscera, liver peliosis, and internal haemorrhage were detected; however, none of these findings were considered to be treatment-related."

From Executive Summary:

"The outcome of pregnancy measured by the number of corpora lutea, implantation sites, resorptions, and live foetuses per litter, was not adversely affected by the treatment. The exposures did not affect embryonal development as measured by weight, crown-rump length, and gross external, visceral, and skeletal examination of the foetuses. Under the conditions of this study, the test substance was not embryotoxic or teratogenic in rats. The NOEC for maternal and developmental toxicity was 50000 ppm, the highest dose tested."

F1 Male and Female Charles River-CD Rats