"For exposure-response array data display purposes, the following results were coded (control and no effect findings were coded as "0", treatment-related increases were coded as "1", and treatment-related decreases were coded as "-1".

Number of fetuses and litters not reported. Using number of does as sample number (n=24)

"LITTER PARAMETERS:

The number of corpora lutea, implants and litter sizes from treated groups did not significantly differ from control values. Pre- and post-implantation loss values were comparable in all groups. The only statistically significant change was the mean for total embryonic deaths that was lower in the high-dose group (0.7) when compared to control (1.3) but this finding has no toxicological significance. Fetal weight was unaffected by treatment and no significant changes were observed on sex ratio."

"EXAMINATION OF FOETUSES:

- Malformations: The number of malformed foetuses/litters observed in control, low, mid and high-dose groups were 4 (4), 6 (6), 2 (2) and 8 (5) respectively, the differences being not statistically significant. Although the incidence of malformed foetuses at 50000 ppm is higher than in controls, as there is no consistent pattern to the type of structural defects observed among foetuses in this group, this finding is considered likely to be coincidental. This increased incidence of malformations in the high-dose group was essentially due to 4 foetuses with microphthalmia compared to 0 in the control group, confined in only 2 litters out of 20 and from study phase 2. Since microphthalmia was not observed among phase 1 litters and overall only 2/20 litters were affected, the higher incidence in this group is considered to be coincidental and unrelated to maternaI exposure. The mean percentage incidence of malformed foetuses at 5000 and 15000 ppm was comparable with controls. No foetuses in these groups showed microphthalmia.

- Minor anomalies: There was no obvious adverse effect of exposure on the incidence of foetuses showing visceral anomalies or skeletal anomalies.

- Skeletal variants: The percentage incidence of foetuses displaying variant sternebrae and 13 ribs were comparable in all groups and did not indicate any adverse effects of exposure."

F1 Male and Female Rabbits