INTRODUCTION: Poly-/per-fluoroalkyl substances (PFAS) are widespread environmental pollutants that may induce metabolic perturbations in humans, including particularly alterations in lipid profiles. Prenatal exposure to PFAS can cause lasting effects on offspring metabolic health, however, the underlying mechanisms are still unknown.

OBJECTIVES: The goal of the study was to investigate the impact of prenatal PFAS exposure on the lipid profiles in cord blood.

METHODS: Herein, we combined determination of bile acids (BAs) and molecular lipids by liquid chromatography with ultra-high-resolution mass spectrometry, and separately quantified cord blood concentrations of sixteen PFAS in a cohort of Chinese infants (104 subjects) in a cross-sectional study. We then evaluated associations between PFAS concentration and lipidome using partial correlation network analysis, debiased sparse partial correlation, linear regression analysis and correlation analysis.

RESULTS: PFAS levels showed significant associations with the lipid profiles; specifically, PFAS exposure was positively correlated with triacylgycerols (TG) and several bile acids. Importantly, exposure to perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorononanoic acid (PFNA) and perfluorohexane sulfonic acid (PFHxS) were associated with increased levels of TGs with saturated fatty acids while multiple classes of phospholipids were decreased. In addition, several free fatty acids showed significant positive correlations with PFOS.

CONCLUSIONS: Our results indicated that prenatal exposure to PFAS mediated metabolic changes, which may explain the associations reported between PFAS exposure and metabolic health later in life.

[Untagged]
━ Included
━ ━ Human
━ ━ ━ Pregnant women
━ ━ ━ ━ Case-control
━ ━ ━ ━ Cohort
━ ━ ━ ━ Cross-sectional
━ ━ ━ Infants
━ ━ ━ ━ Case-control
━ ━ ━ ━ Cohort
━ ━ ━ ━ Cross-sectional
━ ━ ━ Children
━ ━ ━ ━ Case-control
━ ━ ━ ━ Cohort
━ ━ ━ ━ Cross-sectional
━ ━ ━ General population
━ ━ ━ ━ Case-control
━ ━ ━ ━ Cohort
━ ━ ━ ━ Cross-sectional
━ ━ ━ Occupational
━ ━ ━ ━ Case-control
━ ━ ━ ━ Cohort
━ ━ ━ ━ Cross-sectional
━ ━ Animal
━ ━ ━ Acute
━ ━ ━ Short-term
━ ━ ━ Subchronic
━ ━ ━ Chronic
━ ━ ━ Developmental
━ ━ ━ Multigenerational
━ Excluded
━ ━ Manually excluded in SWIFT-Review
━ ━ Automatically excluded via ML in SWIFT-Active Screener
━ ━ Manually excluded in Distiller (TIAB)
━ ━ Manually excluded in Distiller (full-text)
━ ━ ━ No data provided
━ ━ ━ No relevant exposure
━ ━ ━ Unable to obtain full-text
━ ━ ━ Wildlife study
━ Supplemental
━ ━ Mechanistic (in vitro/ex vivo/in silico)
━ ━ ADME
━ ━ PK/PBPK
━ ━ Non-mammalian model
━ ━ Transgenic mammalian model
━ ━ Non-oral or non-inhalation route
━ ━ ━ Exposure duration
━ ━ ━ ━ Acute
━ ━ ━ ━ Short-term
━ ━ ━ ━ Subchronic
━ ━ ━ ━ Chronic
━ ━ ━ ━ Developmental
━ ━ ━ ━ Other/unclear
━ ━ ━ Route of exposure
━ ━ ━ ━ Oral (gavage)
━ ━ ━ ━ Dermal
━ ━ ━ ━ Injection
━ ━ ━ ━ Intravenous
━ ━ ━ ━ Other/unclear
━ ━ Exposure only
━ ━ Mixture
━ ━ Case reports/series (n≤3)
━ ━ No original data
━ ━ Conference abstract
━ ━ ECHA read-across
━ ━ Presumed duplicate
━ ━ Other supplemental
━ Chemicals
━ ━ Not specified
━ ━ 1-Butanesulfonic acid, 1,1,2,2,3,3,4,4,4-nonafluoro-, salt with sulfonium, dimethylphenyl- (1:1)
━ ━ 1-Hexene, 3,3,4,4,5,5,6,6,6-nonafluoro-, polymer with ethene and 1,1,2,2-tetrafluoroethene
━ ━ 1H,1H,2H-Perfluorocyclopentane
━ ━ 1H,1H,5H-Perfluoropentanol
━ ━ 2-Chloro-1,1,1,2-tetrafluoroethane
━ ━ 2H,2H,3H,3H-Perfluorooctanoic acid
━ ━ 3-Methoxyperfluoro(2-methylpentane)
━ ━ 3-Perfluoroheptylpropanoic acid
━ ━ 3,3,4,4,5,5,6,6,6-Nonafluorohexene
━ ━ 4:2 Fluorotelomer alcohol
━ ━ 6:2 Fluorotelomer alcohol
━ ━ 6:2 Fluorotelomer methacrylate
━ ━ 6:2 Fluorotelomer sulfonic acid
━ ━ 8:2 Fluorotelomer alcohol
━ ━ 8:2 Fluorotelomer sulfonic acid
━ ━ Bis(2-hydroxyethyl)ammonium perfluorobutanesulfonate
━ ━ Dodecafluoroheptanol
━ ━ (Heptafluorobutanoyl)pivaloylmethane
━ ━ Heptafluorobutanol
━ ━ Methyl perfluoro(3-(1-ethenyloxypropan-2-yloxy)propanoate)
━ ━ Nafion
━ ━ ━ Included
━ ━ ━ ━ Animal
━ ━ ━ ━ ━ Short-term
━ ━ ━ ━ Human
━ ━ ━ ━ ━ Occupational
━ ━ ━ ━ ━ ━ Cross-sectional
━ ━ ━ Excluded
━ ━ ━ ━ Manually excluded in Distiller (TIAB)
━ ━ ━ ━ Manually excluded in Distiller (full-text)
━ ━ ━ Supplemental
━ ━ ━ ━ ADME
━ ━ ━ ━ Exposure only
━ ━ ━ ━ Mechanistic (in vitro/ex vivo/in silico)
━ ━ ━ ━ Non-mammalian model
━ ━ ━ ━ Non-oral or non-inhalation route
━ ━ ━ ━ ━ Exposure duration
━ ━ ━ ━ ━ ━ Chronic
━ ━ ━ ━ ━ ━ Short-term
━ ━ ━ ━ ━ ━ Subchronic
━ ━ ━ ━ ━ Route of exposure
━ ━ ━ ━ ━ ━ Injection
━ ━ ━ ━ ━ ━ Intravenous
━ ━ ━ ━ ━ ━ Other/unclear
━ ━ ━ ━ Other supplemental
━ ━ ━ Chemicals
━ ━ ━ ━ Nafion
━ ━ N-Ethyl-N-(2-hydroxyethyl)perfluorooctanesulfonamide
━ ━ N-Ethylperfluorooctanesulfonamide
━ ━ N-Methyl-N-(2-hydroxyethyl)perfluorooctanesulfonamide
━ ━ N-Methylperfluorooctanesulfonamide
━ ━ Pentafluoropropanoic anhydride
━ ━ Perfluamine
━ ━ Perfluoro-1,3-dimethylcyclohexane
━ ━ Perfluoro-1-iodohexane
━ ━ Perfluoro-2,5-dimethyl-3,6-dioxanonanoic acid
━ ━ Perfluoro-2-methyl-3-oxahexanoic acid
━ ━ Perfluoro-3-(1H-perfluoroethoxy)propane
━ ━ Perfluoro-3,6-dioxaheptanoic acid
━ ━ Perfluoro(N-methylmorpholine)
━ ━ Perfluoro(propyl vinyl ether)
━ ━ Perfluorobutanesulfonyl fluoride
━ ━ Perfluorocyclohexanecarbonyl fluoride
━ ━ Perfluoroheptanesulfonate
━ ━ Perfluoroheptanesulfonic acid
━ ━ Perfluoroheptanoic acid
━ ━ Perfluoroisobutyl methyl ether
━ ━ Perfluoromethylcyclopentane
━ ━ Perfluorooctanesulfonamide
━ ━ Perfluorooctanesulfonyl fluoride
━ ━ Perfluoropentanoic acid
━ ━ Perfluoropropanoic acid
━ ━ Perfluorotetradecanoic acid
━ ━ Perfluorotridecanoic acid
━ ━ Perfluoroundecanoic acid
━ ━ Propanoic acid, 3-[1-[difluoro[(trifluoroethenyl)oxy]methyl]-1,2,2,2-tetrafluoroethoxy]...
━ ━ Sodium perfluorodecanesulfonate
━ ━ Tetrabutylphosphonium perfluorobutanesulfonate
━ ━ Tetraethylammonium perfluorooctanesulfonate
━ ━ Trichloro((perfluorohexyl)ethyl)silane
━ ━ Triethoxy((perfluorohexyl)ethyl)silane
━ ━ Trifluoroacetic acid
━ ━ Trifluoromethanesulfonic acid
━ ━ 3:3 Fluorotelomer carboxylic acid
━ ━ 4:2 Fluorotelomer sulfonic acid
━ ━ Perfluoro(2-methyl-3-oxahexanoyl) fluoride
━ ━ Propane, 1,1,1,2,2,3,3-heptafluoro-3-[(trifluoroethenyl)oxy]-, polymer with tetrafluoroethene
━ ━ Perfluoro-3-methoxypropanoic acid
━ ━ Perfluoro(4-methoxybutanoic) acid

References (17373 found)