Harris, 1989, 3858729

Study evaluation

Animal bioassay experiments

NameTypeComments
Gestational Oral (GD 10-13) Developmental

"On each day of dosing, all of the mice were weighed and treated by gavage ( 10 ml/kg body wt). Control mice received 10 ml/kg body wt corn oil (Mazola Brand) each dosing day. The mice were dosed once per day for either 4 consecutive days (gd 10-13) or 10 consecutive days (gd 6-15). The initial study (gd 10--13) was done to expose mice during the gestational period containing the "window of sensitivity" for cleft palate and hydronephrosis development after exposure to TCDD (Birnbaum et al .. 1985). After the results from this exposure were evaluated, the compound was administered during the entire period of organogenesis (gd 6-15 )."

Gestational Oral (GD 6-15) Developmental

"On each day of dosing, all of the mice were weighed and treated by gavage (10 ml/kg body wt). Control mice received 10 ml/kg body wt corn oil (Mazola Brand) each dosing day. The mice were dosed once per day for either 4 consecutive days (gd 10-13) or 10 consecutive days (gd 6-15). The initial study (gd 10-13) was done to expose mice during the gestational period containing the "window of sensitivity" for cleft palate and hydronephrosis development after exposure to TCDD (Birnbaum et al .. 1985). After the results from this exposure were evaluated, the compound was administered during the entire period of organogenesis (gd 6-15 )."