2-year drinking water study in F344/N rats and B6C3F1 mice.

Note: time weighted average daily doses, or mg/kg-d (ADD) represent the time weighted average over the course of 2 years using weekly consumption data from the NTP report. As a result, the nominal mg/kg-d, or the mg/kg-d (ADD) may not be accurate for animals with different observation times (ie, 4, days, 22 days, 3 months, 6 months, or 12 months). At earlier time points, rodents ingested a higher dose due to greater water consumption during the growth period.